LOX-1相关论文
目的:运用siRNA技术敲减db/db小鼠骨组织LOX-1,通过骨密度、骨小梁、骨形成和骨吸收指标的检测,探讨LOX-1对2型糖尿病性骨质疏松症......
缺血性脑卒中作为当今致残率第一、死亡率第二的脑血管类疾病已经严重威胁到人类的健康,给社会也带来沉重负担,然而目前治疗该疾病......
目的:颈动脉粥样硬化(carotid atherosclerosis,CAS)是一种脂质在动脉壁过度积累为主要特征的慢性血管炎症性疾病。CAS可引起大脑的......
目的:探究β-紫罗兰酮(β-ionone,BI)在烟曲霉菌(Aspergillus fumigatus,A.fumigatus)感染的角膜炎中的保护作用及其作用机制。方法:1......
第一部分 LOX-1在骨关节炎患者中的表达及临床意义目的:评价LOX-1和ox-LDL在骨关节炎患者中的水平变化,明确LOX-1和ox-LDL与骨关节......
目的:研究子痫前期(preeclampsia,PE)微小RNA(miR)-146a及氧化低密度脂蛋白(ox-LDL)的表达,及其在子痫前期发病机制中的作用。方法:选择2......
Dihydrotanshinone Ⅰ inhibits LPS induced LOX-1 expression via TLR4/ROS/NF-κB signal pathway in human
Aim: Lectin-like receptor for oxidized low density lipoprotein (LOX-1) has been implicated as the main receptor for oxid......
Purpose To determine the role of lectin-like oxidized low-density lipoprotein receptor 1(LOX-1)in corneal epithelial cel......
Aim: Oxidized low-density lipoprotein (ox-LDL) is a main etiologic factor in atherogenesis, and antioxidants are accepte......
Aim: The present study investigated the effects of WS070117, a novel small molecule compound, on foam cell formation, an......
Purpose: To determine the role of lectin-like oxidized low-density lipoprotein receptor l(LOX-I)in comeal epithelial cel......
背景:LOX-1是表达于内皮细胞膜上的ox-LDL的主要受体,在动脉粥样硬化(atherosclerosis,AS)发生、发展过程中起重要作用.二氢丹参酮......
Dihydrotanshinone I Attenuates Atherosclerosis in ApoE-deficient Mice: Role of NOX4/NF-κB Mediated L
Dihydrotanshinone I (DHT) is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for ......
Hydrogen-rich saline inhibit TNF-α-induced nuclear factor κ B (NF-κ B)activation and lectin-like oxi
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Aim: To investigate the effect and possible mechanisms of oleanolic acid (OA) in preventing endothelial cell oxidative i......
Cryptotanshinone,an orally bioactive herbal compound from Danshen,attenuates atherosclerosis in Apol
BACKGROUND AND PURPOSE: Cryptotanshinone (CTS) is a major bioactive diterpenoid isolated from Danshen, an eminent medici......
Abrogation of lectin-like oxidized LDL receptor-1 attenuates acute myocardial ischemia-induced renal
Objective To It is assumed, but never proven, that acute myocardial infarction affectsrenal function. We tested this phe......
四氯苯醌(TCBQ)是由除草杀虫用剂五氯酚(PCP)代谢产生[1]。有实验表明,四氯苯醌(TCBQ)能促发体内氧化应激水平,增加ROS的形成[1]。......
系统性红斑狼疮(SLE)是一种累及多器官多系统的典型的自身免疫性疾病。近年的研究表明,髓源抑制性细胞(MDSCs)是一群异质性的未成......
Effect of Candesartan Combined with Rosuvastatin on Myocardial Fibrosis in Rats with Alcoholic Cardi
Objective:To analyze the effect of candesartan and rosuvastatin on myocardial fibrosis in rats with alcoholic cardiomyop......
目的探讨左西孟旦(levosimendan,Levo)对冠状动脉微栓塞(coronary microembolization, CME)后心肌损伤和LOX-1/p38 MAPK信号通路的影响......
Vasodegenerative disease, like other so-called diseases of aging, begins decades before it becomes clinically appare......
近年来,脂代谢异常与子痫前期的发病关系已受人们关注。目前研究证实,凝集素样氧化低密度脂蛋白受体-1(the lectin-like oxidized ......
该研究针对LOX-1基因(OLR1)设计并合成3条siRNA干扰序列,与双酶切的U6-vshR-NA-CMV-GFP慢病毒载体连接得到重组载体,包装慢病毒并测定......
目的:靶向血凝素样氧化型低密度脂蛋白受体-1(LOX-1)基因的发卡样siRNA(shRNA)表达载体的构建及其对巨噬细胞源性泡沫细胞形成的影......
目的探讨血凝素样氧化低密度脂蛋白受体-1(LOX-1)对急性脑卒中患者恢复情况的预测价值。方法选择2014年1月至2015年6月在上海市徐汇......
目的:动脉血管内皮下巨噬细胞对胆固醇酯特别是氧化低密度脂蛋白(ox-LDL)摄取和流出的不平衡被认为是导致泡沫细胞形成及早期动脉......
[目的]本实验通过观察不同浓度黄芪含药血清对脂多糖刺激人脐静脉内皮细胞TLR4、LOX-1、PI3K及p-Akt的影响,从而探讨其抑制动脉粥......
背景心肌梗死后心室重构(Ventricular remodeling,VR)是指急性心肌梗死(Acute myocardial infarction,AMI)后心脏在受到损伤或超负......
目的:心肌缺血/再灌注损伤(myocardial ischemia reperfusion-injury,MIRI)降低了血运重建的疗效。心肌缺血/再灌注后,凝集素样氧......
研究目的:探讨8周有氧运动和二甲双胍干预对2型糖尿病小鼠血管内皮功能、糖脂代谢、炎症反应及主动脉LOX-1、NF-κBp65和Caspase-3......
目的:探究氧化型低密度脂蛋白对肝窦内皮细胞LOX-1表达情况,并分析其机制。方法:采用Real-time PCR方法和蛋白免疫印迹法分别检测L......
目的了解人巨细胞病毒(HCMV)感染对兔平滑肌细胞(SMC)凝集素样氧化型低密度脂蛋白受体-1(LOX-1)表达的影响,探讨HCMV在动脉粥样硬......
目的构建人C-反应蛋白(C-reactive protein,CRP)重组表达质粒pTracer CMV2-CRP,并观察其在人脐静脉内皮细胞(Human umbilical vein......
目的构建血凝素样氧化低密度脂蛋白受体-1(LOX-1)真核表达载体,筛选高表达菌株,为体外获得有活性重组蛋白奠定基础。方法以实验室......
目的 探讨LOX-1基因G501C位点多态性与腔隙性脑梗死发病的相关性.方法 用PCR-LDR方法检测167例腔隙性脑梗死患者和386例健康对照者......
动脉粥样硬化过程是大血管及中血管的一种慢性炎症,大量研究表明,在心血管病患者血清中氧化型低密度脂蛋白(oxidized low-density ......
氧化低密度脂蛋白(ox-LDL)及其脂质成分是致动脉粥样硬化(AS)形成的重要分子,在AS形成早期,ox-LDL及其脂质成分所致的内皮功能障碍......